Adhatoda vasica. Justicia adhatoda
دیگر نام: برگ بانسہ برگ اڑوسہ وساکا حشیشتہ السعال
Watch also previous video on Adhatoda vasica:
Adhatoda vasica || Justicia adhatoda Previous Video.
Malabar Nut, Berg e Bansa, Adhatoda, Vasaka Full Details.
Contact for further details:
Adhatoda vasica / Justicia adhatoda commonly known in English as Malabar nut, adulsa, adhatoda, vasa, vasaka, is native to Asia. The plant's native range is Afghanistan, Pakistan, Imdia, Laos, Myanmar and Vietnam. It has been introduced elsewhere.
Adhatoda vasica (family Acanthaceae, AV) is a shrub, used by Asian and European medical practitioners. This plant has been used in the Indian traditional system of medicine (Manjunath 1948). Numerous in vitro, in vivo, and clinical studies have acknowledged AV(Adhatoda vasica) as an important natural agent for many medical illnesses. AV has an antiinflammatory action on the respiratory tract and is effective in respiratory tract infection. The alkaloids vasicinone and vasicine have potent bronchodilator and antiallergic activity. Owing to these activities, AV is effective in acute asthma conditions. AV has been proven for its antitussive activity as effective as codeine in irritant aerosols and citric acid-induced cough models. The leaves, roots, flowers, and bark of this plant have been used in the treatments of cough, colds, asthma, to liquefy sputum, as a bronchodilator, bronchial catarrh, bronchitis, and tuberculosis. A number of parts of the plant are commonly used in the forms of decoctions or powders. The juice from the leaves is also frequently used (Claeson et al., 2000). Vasaka syrup and vasaka liquid extract are mentioned in Pharmacopoeia of India (The Indian Pharmacopoeia), (1955). An essential oil extracted from the leaves of AV showed a relaxant effect on the airway smooth muscle in the isolated guinea pig tracheal chain (D’Cruz et al., 1979). A methanolic extract from the whole plant showed antiallergic and antiasthmatic properties in the guinea pig (Muller et al., 1993). Many herbal preparations containing AV are commercially used, such as Kada in India, Salus Tuss in Germany, and Kan Jang and Spirote in Sweden (Claeson et al., 2000). Vasicine, an alkaloid, is one of the major components of the plant and is responsible for most of its activities, including its antioxidant, antiinflammatory, and bronchodilatory qualities. Bromhexine, a derivative of vasicine, has been shown to possess mucus-liquefying/expectorant activity. A clinical trial was conducted with bromhexine in 30 patients suffering from different respiratory symptoms. A significant change in the viscosity and acid mucopolysaccharide structure was found in the bromhexine-treated group as compared to the placebo group, and this was seen in both infected and noninfected patients. Ambroxol, a widely used secretolytic agent developed from vasicine, was shown to inhibit IgE-dependent mediator secretion from human MCs and basophils—the principal effectors of allergic inflammation. As compared to vasicine, ambroxol showed a greater effect in lowering basophil IL-4 and IL-13 secretions. It was also reported to reduce IgE-dependent p38 mitogen-activated protein kinase (MAPK) phosphorylation in basophils (Rachana et al., 2011).
------------------------------------
To find immediately applicable drug for the treatment of COVID-19 positive patients, a plausible life cycle of this virus is proposed from the analysis of few case reports. On the basis of this proposal and symptomatic similarities few common drug-molecules are tested as protease inhibitor and replicase inhibitor of COVID-19 virus using COVID-19 Docking Server. It is observed that anisotine and vasicoline of Justicia adhatoda and Pemirolast are very good inhibitors. As all these three compounds are market available drugs, immediate clinical trial is plausible which may lead to the golden success against the present pandemic. We prescribed different drugs for different purpose and stages of viral infection.
Reference.
Bag A, Bag A. Treatment of COVID-19 patients: Justicia adhatoda leaves extract is a strong remedy for COVID-19 – Case report analysis and docking based study. ChemRxiv. Cambridge: Cambridge Open Engage; 2020; This content is a preprint and has not been peer-reviewed.
#cough #malabarnut #bansa #bhankar #vasaka #adhatodavasica #Justiciaadhatoda #plants #herbalmedicine
No comments:
Post a Comment